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She guest-starred on The West Wing, was a voice on King of the Hill, and was a lesbian who coaxes Ellen De Generes out of the closet in the famous 1997 "The Puppy Episode" of the television series Ellen.
Laura Dern's film debut was an appearance in her mother's film White Lightning (1973).
Dern is also an activist for raising awareness about toxic substances that can affect children's health.
She is also a supporter of various charities and is also an activist for Down syndrome awareness.
On November 1, 2010, she received the 2,420th star on the Hollywood Walk of Fame.
Her parents, Diane Ladd and Bruce Dern, were also presented with stars.